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Purpose of
Study:
To determine the effectiveness of natural products in increasing the function
of Natural Killer (NK) cell activity in chronic illnesses. In this study persons
suffering from Fibromyalgia were chosen to take part in an in vivo study.
Background: It is felt that
chronic illnesses represent immune system failures in most instances,
particularly in the Fibromyalgia Syndrome. There have been many
published reports of low Natural Killer cell activity or function in persons
with Fibromyalgia.
Natural
Killer Cells: Natural Killer cells are the first line of defense in our innate
immune systems. They are lethal lymphocytes containing granules filled
with potent chemicals. They do not need to recognize a particular antigen but
rather attack "nonself". NK cells protect against and target
tumor cells and a wide variety of infectious microbes, particularly virally
infected cells. NK cells kill by binding to their targets and
delivering a lethal burst of chemicals that produce holes in the target
cell's membrane. Fluids seep in and leak out and the cells burst and die.
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NK cells
protect against and target tumor cells and a wide variety of infectious
microbes, particularly virally infected cells. NK cells kill by binding to
their targets and delivering a lethal burst of chemicals that produce holes
in the target cell's membrane. Fluids seep in and leak out and the cells
burst and die.
Patient
Selection: Nine patients were enrolled in the study who had been diagnosed with
Fibromyalgia and who weren't taking any known immune stimulants at the time
of enrollment.
Name:
Transfer
Factor Plus™ Dosage: One, twice daily, days 1-10. Two, twice daily,
days 11-20.
Length
of Study: Blood work was drawn on day 1 before the beginning of the use of the
products and on day 21 after using the products for 20 consecutive days.
Methodology: The patient's blood
was drawn and peripheral blood mononuclear cells were isolated and NK cell
activity was assessed by a variation of the 51Cr release assay. The
target cells were live K562 erytholeukemic cells. NK cytolytic activity
was calculated at the baseline of day 1 and on the 21st day.
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Comment: If a person has a Natural Killer
cell activity below 20%, he or she is more susceptible to acute or chronic
illnesses, or to have a compromised ability to recover from existing
illnesses. All of the nine volunteers had NK cell function of less than
20% activity with a range of 6 to 13%, and an average of the group of 10%
activity.
Summary: All of the nine
patients had significant increases in Natural Killer cell activity. The
levels after 20 days on the products now ranged from 19.5% to 35.5% with an
average of 26.9%. This represented an NK cell activity which is 269% of
the zero baseline level or a 169% increase in individual NK activity.
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Prior in vitro testing of Transfer Factor Plus revealed an increase in
activity of 248%. This in vivo testing confirms and validates the in vitro testing
done earlier by an independent laboratory analysis of Transfer Factor Plus.
Rob
Robertson, M.D.
*Products provided by 4Life Research™, LC 2066 South 950
East, Provo, UT 84606.
Regreso
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